Resumen
Introduction: Gastric cancer is the fourth leading cause of cancer death worldwide. Its histological and anatomical classification can predict the clinical and prognostic behavior of the disease. According to Lauren's classification, it is divided into intestinal, diffuse, and mixed types, anatomically it can be divided into proximal and distal. Intestinal and proximal tumors show the best prognosis. H. pylori infection is considered the leading cause of gastric cancer worldwide. Even though there is a high prevalence of gastric cancer in Guatemala, there are few studies that provide information on its characteristics.
Objective: To describe the endoscopic and histological characteristics of gastric cancer in an endoscopic center in Guatemala.
Methods: Descriptive, retrospective, observational study carried out with records of patients diagnosed at the Gastro Centro S.A. center. Endoscopic and histopathological reports of patients diagnosed with gastric cancer during the years 2018 to 2022 were reviewed.
Results: 102 cases of gastric cancer were found, of which 99 corresponded to adenocarcinomas. The mean age of the patients was 57.57 ± 16.34 years, of which 57 (55.58%) were men. The diffuse type was the most frequent histopathological variant with 48 (48.5%) cases. Anatomically, 55 (55.6%) of the cases were distal tumors. The presence of H. pylori was identified in 78 (78.8%) of the tumors.
Key words: Gastric cancer, gastric tumor, gastric adenocarcinoma, gastric histology, H. pylori.
Citas
Sung, H., Ferlay, J., Siegel, R.L., Laversanne,M., Soerjomataram, I., Jemal, A., Bray, F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer J Clin. 2021, May/June; 71(3): 209-249. https://doi.org/10.3322/caac.21660
Instituto de Cancerología y Hospital "Dr. Bernardo Del Valle S". Informe de casos nuevos de cáncer y defunciones registradas en el Instituto de Cancerologia y Hospital “Dr. Bernardo del Valle S.” -INCAN- de la Liga Nacional contra el Cancer durante el año 2019, por el Registro de cancer del -INCAN- Guatemala. 2022, Dec.; 17(5): 36–45. https://34cdd47e-6421-47cf-8cd6-560fce0dda4a.filesusr.com/ugd/c472b0_802588b371a34145bc1856d25ede1528.pdf
Karimi, P., Islami, F., Anandasabapathy, S., Freedman, N.D., Kamangar, F. Gastric cancer: descriptive epidemiology, risk factors, screening, and prevention. Cancer Epidemiol Biomarkers Prev. 2014, May; 23(5): 700-713. DOI: 10.1158/1055-9965.EPI-13-1057 doi: 10.1158/1055-9965.
Lauren, P. The two histological main types of gastric carcinoma. Diffuse and so-called Intestinal type carcinoma: An attempt at a histo-clinical classification. Acta Patho Microbiol Scand. 1965, Sept.; 64: 31-49. https://doi.org/10.1111/apm.1965.64.1.31
Qiu, M.Z., Cai, M.Y., Zhang, D.S., et al. Clinicopathological characteristics and prognostic analysis of Lauren classification in gastric adenocarcinoma in China. J Transl Med. 2013, Mar; 11: 58. https://doi.org/10.1186/1479-5876-11-58
Martínez-Galindo, M.G., Zamarripa-Dorsey, F., Carmona-Castañeda, A., et al. Histopathologic characteristics of gastric adenocarcinoma in Mexican patients: a 10-year experience at the Hospital Juárez of Mexico. Rev Gastroenterol Mex. 2015, Jan-Mar; 80(1): 21-26. English, Spanish. DOI: 10.1016/j.rgmx.2014.11.002
Zhang, Y., Zhang, P.S., Rong, Z.Y. Huang, C. One stomach, two subtypes of carcinoma-the differences between distal and proximal gastric cancer. Gastroenterol Rep (Oxf). 2021, Nov.; 9(6): 489-504. DOI: 10.1093/gastro/goab050 .
Duchon, R., Bernadic Jr., M., Pindak, D. Impact of the anatomical location and the number of metastatic lymph nodes on gastric cancer patient’s survival. Bratisl Lek Listy. 2020; 121(4): 253-258. DOI: 10.4149/BLL_2020_038 .
Karimi, P., Islami, F., Anandasabapathy, S., Freedman, N.D., Kamangar, F. Gastric cancer: descriptive epidemiology, risk factors, screening, and prevention. Cancer Epidemiol Biomarkers Prev. 2014, May; 23(5): 700-713. DOI: 10.1158/1055-9965.EPI-13-1057.
Correa, P., Piazuelo, M.B. The gastric precancerous cascade. J Dig Dis. 2012, Jan; 13(1): 2-9. DOI: 10.1111/j.1751-2980.2011.00550.x.
González, C.A., Megraud, F., Buissonniere, A., et al. Helicobacter pylori infection assessed by ELISA and by immunoblot and noncardia gastric cancer risk in a prospective study: the Eurgast-EPIC project. Ann Oncol, 2012, May; 23(5): 1320–1324. DOI: 10.1093/annonc/mdr384
Matta de García, V.L., & De León, J.L. Caracterización del cáncer gástrico en Guatemala. Revista Científica Facultad de Ciencias Químicas y Farmacia, 2015, Dec.; 25(2): 9–20. DOI: https://doi.org/10.54495/Rev.Cientifica.v25i2.87
Díaz, Y.A., de León, J.L., Rivera, L.E., & Matta, V.L. Prevalencia de la infección por Helicobacter pylori en la población que asistió a las clínicas de APROFAM durante 2006-2011. Ciencia, Tecnología y Salud, 2017, Dec.: 4(2): 226. DOI: https://doi.org/10.36829/63CTS.v4i2.235
Muñoz-Cedeño, R.G., Martínez, P., Paullán-Sani, V., Rodríguez-Chica, G. Caracterización clínica, histológica y endoscópica del cáncer gástrico en el Hospital de Especialidades Dr. Abel Gilbert Pontón, Ecuador. Rev Colomb Gastroenterol. 2021, Abril-Junio; 36(2): 163-171. DOI: https://doi.org/10.22516/25007440.558
Quevedo Alvarado, L., Justiano, M. Perfil clínico, epidemiológico y terapéutico de pacientes con cáncer gástrico. Estudio descriptivo realizado en los Hospitales Generales San Juan de Dios y Hospittal Roosevelt: enero de 2005 a junio de 2011. Tesis Médico y Cirujano. Universidad de San Carlos de Guatemala, Facultad de Ciencias Médicas. 2011, 08; 75 p. https://biblioteca.medicina.usac.edu.gt/tesis/pre/2011/079.pdf
Zhang, J., Gan, L., Xu, M.D., et al. The prognostic value of age in non-metastatic gastric cancer after gastrectomy: a retrospective study in the U.S. and China. J Cancer, 2018, Mar.; 9(7): 1188-1199. doi:10.7150/jca.22085 .
Tavares, A., Gandra, A., Viveiros, F., Cidade, C., Maciel, J. Analysis of clinicopathologic characteristics and prognosis of gastric cancer in young and older patients. Pathol Oncol Res. 2013, Jan.; 19(1): 111-117. DOI: 10.1007/s12253-012-9530-z.
Matta de García, V.L. Asociación entre las Infecciones por Helicobacter Pylori Y Epstein Bar y la presencia de cáncer gástrico en pacientes que acuden al INCAN. Proyecto Fodecyt No. 11-2017. 2018, Mayo; 11: 162 p. https://fondo.senacyt.gob.gt/portal/images/yootheme/FODECYT-2017-11_compressed.pdf
Rawla, P., Barsouk, A. Epidemiology of gastric cancer: global trends, risk factors and prevention. Prz Gastroenterol. 2019, Nov.; 14(1): 26-38. DOI: 10.5114/pg.2018.80001.
Lee, Y.C., Chiang, T.H., Chou, C.K., et al. Association Between Helicobacter pylori Eradication and Gastric Cancer Incidence: A Systematic Review and Meta-analysis. Gastroenterology. 2016, May; 150(5): 1113-1124.e5. DOI: 10.1053/j.gastro.2016.01.028
Malfertheiner, P., Megraud, F., Rokkas, T., et al. Management of Helicobacter pylory infection: the Maastricht VI/Florence consensus report. Gut. 2022, Aug.; 8:gutjnl-2022-327745. DOI: 10.1136/gutjnl-2022-327745 .
Hu, B., El, Hajj, N., Sittler, S., Lammert, N., Barnes, R., Meloni-Ehrig, A. Gastric cancer : Classification, histology and application of molecular pathology. J Gastrointest Oncol. 2012, Sep; 3(3): 251-261. DOI: 10.3978/j.issn.2078-6891.2012.021 .
Copyright
License
Copyright (c) 2023 Mynor Aguilar Hernández, Francisco Alvarado Muñoz

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Authors who publish in this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial-ShareAlike License 4.0 (CC BY-NC_SA 4.0) that indicates: a) It is allowed that others share the work, with an acknowledgement of the work's authorship and initial publication in this journal, b) The work may not be used for commercial purposes, c) If it's remixed, transformed, or built upon the material, one must distribute the contributions under the same license as the original
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository, website or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.