Resumen
Introduction. The pandemic caused by the Sars-Cov-2 virus has made it possible to focus on the study of inflammatory markers of severity, epidemiological and clinical data that allow predicting the patient's prognosis. Research from other countries has shown that the elevation of cardiac enzymes has been correlated with cardiac damage in patients with COVID-19, especially in patients with associated comorbidities. Objective: The main objective is to determine if there is a relationship between comorbidities (DM II and HTA) and the elevation of cardiac enzymes in infected patients. Methodology: Prospective observational study in which the sample was collected from the Hospital General de Enfermedades zona 9 (IGSS) and a total of 546 patients were selected. Results: There is no statistically significant difference between elevated cardiac enzymes levels (CKMB, Troponin I) and patients with a history of DM II and HTA (p= 0.6748). Conclusion: No significant difference of creatine kinase MB or troponin I was shown bewteen the groups with and without comorbidities.
Citas
World Health Organization. Novel Coronavirus (2919-nCoV) : Situation report – 1. 2020, January. Geneva, Switzerland: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200121-sitrep-1-2019-ncov.pdf?sfvrsn=20a99c10_4
Johns Hopkins. COVID-19 Dashboard by the Center for Systems Science and Engineering (CCSE) at Johns Hopkins University. Coronavirus Resource Center. 2023., February. https://coronavirus.jhu.edu/map.html
Ejaz, H., Alsrhani, A., Zafar, A., Javed, H., Junaid, K., Ebdalla, A.E., Abosalif, K.O.A., Ahmed, Z., Younas, S. COVID-19 and comorbidities: Deleterious impact on infected patients. Journal of Infection and Public Health, 2020, Dec.; 13(12): 1833-1839. https://doi.org/10.1016/j.jiph.2020.07.014 https://pubmed.ncbi.nlm.nih.gov/32788073/
Zhou F., Yu, T. Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., Guan, L., Wei, Y., Li, H., Wu, X., Xu, J., Tu, S., Zhang, Y., Chen, H., Cao, B. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet, 2020, March; 395(10229): 1054-1062. https://doi.org/10.1016/S0140-6736(20)30566-3 https://www.thelancet.com/action/showPdf?pii=S0140-6736%2820%2930566-3
Huang, C., Wang, Y., Li, X., Ren. L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., Cheng, Z., Yu, T., Xia, J., Wei, Y., Wu, W., Xie, X., Yin, W., Li, H., Liu, M., Xiao, Y., Gao, H., Guo, Li., Xie, J., Wang, G., Jiang, R., Gao, Z., Jin, Q., Wang, J., Cao, B. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, 2020, February; 395(10223): 497-506. https://doi.org/10.1016/S0140-6736(20)30183-5 https://www.thelancet.com/article/S0140-6736(20)30183-5/fulltext#%20
Guo, T., Fan, Y., Chen, M., Wu, X., Zhang, L., He, T., Wang, H., Wan, J., Wang, X., Lu, Z. Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID19). JAMA Cardiol, 2020, March; 5(7): 811-818. https://doi.org/10.1001/jamacardio.2020.1017 https://jamanetwork.com/journals/jamacardiology/fullarticle/2763845
Calvo-Fernández, A., Izquierdo, A., Subirana, I., Farré, N., Vila, J., Durán, X., García-Guimaraes, M., Valdivielso, S., Cabero, P., Soler, C., García-Ribas, C., Rodríguez, C., Llagostera, M., Mojón, D., Vicente, M., Solé-González, E. , Sánchez-Carpintero, A., Tevar, C., Marrugat, J., Vaquerizo, B. Markers of myocardial injury in the prediction of short-term COVID-19 prognosis. Revista Española de Cardiología, 2021, July; 74(7): 576-583. https://doi.org/10.1016/j.rec.2020.09.011 https://www.revespcardiol.org/en-markers-myocardial-injury-in-prediction-articulo-S188558572030414X
Chen, C., Chen, C., Yan, J., Zhou, N., Zhao, J., Wang D., Xin, Z., Guan, X., Zhi, Z.H. Analysis of myocardial injury in patients with COVID-19 and association between concomitant cardiovascular diseases and severity of COVID-19. Chinese Journal of Cardiology, 2020, July; 48(7): 567-571. https://doi.org/10.1016/j.lfs.2020.117723 https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-5104
Babapoor-Farrokhran, S., Gill, D., Walker, J., Rasekhi, R. T., Bozorgnia, B., & Amanullah, A. Myocardial injury and COVID-19: Possible mechanisms. Life Sciences, 2020, July; 15; 253: 117723. https://doi.org/10.1016/j.lfs.2020.117723 https://pubmed.ncbi.nlm.nih.gov/32360126/
Copyright
License
Copyright (c) 2021 Bishara Yusef Nayef Judeh Khoury y Luis Arturo Rodríguez Cifuentes

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Authors who publish in this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial-ShareAlike License 4.0 (CC BY-NC_SA 4.0) that indicates: a) It is allowed that others share the work, with an acknowledgement of the work's authorship and initial publication in this journal, b) The work may not be used for commercial purposes, c) If it's remixed, transformed, or built upon the material, one must distribute the contributions under the same license as the original
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository, website or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.