Resumen
Introduction: Atopic dermatitis is a chronic skin disease characterized by the appearance of erythematous, pruritic patches on the skin that can affect up to 20% of the pediatric population. Currently, the exact cause of the disease is unknown and its management uncertain; however, the use of vitamin supplements may be related to a preventative state and improvement in quality of life. Objective: Correlate serum vitamin D levels with the severity of atopic dermatitis in pediatric patients from 0 to 17 years of age in San Juan, Sacatepéquez, Guatemala. Methodology: A descriptive and analytical prospective study was carried out using statistical correlation analysis. This study was conducted in private practice pediatric clinics in San Juan Sacatepéquez and at Bárbara Health Center in San Juan Sacatepéquez, Guatemala. Patients: A total of 55 patients who consulted the private clinics and the Barbara Health Center for atopic dermatitis were included. They underwent a physical examination to determine the atopic dermatitis severity index (SCORAD). Serum vitamin D levels were assessed and correlated with the severity of atopic dermatitis using the SCORAD. Results: Patients with higher SCORAD values tend to have lower vitamin D levels (ng/ml) (R = -0.1929) (R2 =0.04) (p=0.16). Conclusion: The study demonstrated an inverse correlation between serum vitamin D levels and SCORAD although not statistically significantly.
Citas
Nutten, S. Atopic dermatitis: global epidemiology and risk factors. Annals of nutrition & Metabolism. 2015, April; 66 Suppl 1: 8-16. https://doi.org/10.1159/000370220
Thomsen, S.F., Elmose, C., Szecsi, P.B., Stender, S., Kyvik, K.O., Backer, V., Pontoppidan Thyssen, J. Filaggrin gene loss-of-function mutations explain discordance of atopic dermatitis within dizygotic twin pairs. International journal of dermatology. 2016, Dec.; 55(12): 1341-1344. https://doi.org/10.1111/ijd.13401
Ridao i Redondo, M. Dermatitis atópica. Pediatría Integral. 2012, Abril; XVI(3): 213-221.https://www.pediatriaintegral.es/numeros-anteriores/publicacion-2012-04/dermatitis-atopica/
Escarrer Jaume, M.; Guerra Pérez, M.T. Dermatitis atópica. Protoc diagn ter pediatr. 2019; 2; 161-75. https://www.aeped.es/sites/default/files/documentos/11_dermatitis_atopica.pdf
Stalder, J.F., Taïeb. A., Atherton. D.J., et al. Severity scoring of atopic dermatitis: The SCORAD index: Consensus report of the European task force on atopic dermatitis. Dermatology. 1993; 186(1): 23-31. https://doi.org/10.1159/000247298
Gerbens, L.A.A., Prinsen, C.A.C., Chalmers, J.R., Drucker, A.M., von Kobyletzki, L.B., Limpens, J., Nankervis, H., Svensson, A., Trewee, C.B., Zhang, J., Apfelbacher, C.J., Splus, P.I. Evaluation of the measurement properties of symptom measurement instruments for atopic eczema: a systematic review. Allergy. 2017, January; 72(1): 146-163. https://doi.org/10.1111/all.12959
Eichenfield, L.F., Tom, W.L., Chamlin, S.L., Feldman, S.R., Hanifin, J.M., Simpson, E.L., Berger, T.G., Bergman, J.N., Cohen, D.E., Cooper, K.D., Cordoro, K.M., Davis, D.M., Krol, A., Margolis, D.J., Paller, A.S., Schwarzenberger, K., Silverman, R.A., Wiulliams, H.C., Elmets, C., Block, J., Harrod, C.G., Smith Begolka, W., Sidbury, R. Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis. Journal of the American Academy of Dermatology. 23014, February; 70(2): 338-351. https://doi.org/10.1016/j.jaad.2013.10.010
Van Bever, H.P., Nagarajan, S., Shek, L.P., Lee, B.-W. OPINION: Primary prevention of allergy - Will it soon become a reality? Pediatric Allergy and Immunology. 2016, Feb.; 27(1): 6-12. https://doi.org/10.1111/pai.12497
Schlichte, M.J., Vandersall, A., Katta, R. Diet and eczema: a review of dietary supplements for the treatment of atopic dermatitis. Dermatology practical & conceptual. 2916, July; 6(3): 23-29. https://doi.org/10.5826/dpc.0603a06
Christakos, S., Ajibade, D.V., Dhawan, P., Fechner, A.J., Mady, L.J. Vitamin D: metabolism. Endocrinology and metabolism clinics of North America. 2010, June; 39(2): 243-253. https://doi.org/10.1016/j.ecl.2010.02.002
Zittermann, A., and Gummert, J.F. Nonclassical vitamin D actions. Nutrients. 2010, March; 2(4): 408-425. https://doi.org/10.3390/nu2040408
Vaughn, A.R., Foodlad, N., Maarouf, M., Tran, K.A., Shi, V.Y. Micronutrients in Atopic Dermatitis: A Systematic Review. Journal of alternative and complementary medicine. 2019, June; 25(6): 567-577. https://doi.org/10.1089/acm.2018.0363
Yang, A.-R. Kim, Y.-N. & Lee, B.-H. Dietary intakes and lifestyle patterns of Korean children and adolescents with atopic dermatitis: Using the fourth and fifth Korean National Health and Nutrition Examination Survey (KNHANES IV,V), 2007-11. Ecology of food and nutrition. 2016, January; 55(1): 50-64. https://doi.org/10.1080/03670244.2015.1072813
Kim, M. J., Kim, S.N., Lee, Y.W., Choe, Y.B. and Ahn, K.J. Vitamin D Status and Efficacy of Vitamin D Supplementation in Atopic Dermatitis: A Systematic Review and Meta-Analysis. Nutrients. 2016, Dec.; 8(12): 789. https://doi.org/10.3390/nu8120789
López Carrera, Y.I., Al Hammadi, A., Huang, Y.H., Llamado, L.J., Mahgoub, E., Tallman, A.M. Epidemiology, Diagnosis, and Treatment of Atopic Dermatitis in the Developing Countries of Asia, Africa, Latin America, and the Middle East: A Review. Dermatology and therapy (Heidelb). 2019, Oct.; 9(4): 685-705. https://doi.org/10.1007/s13555-019-00332-3
Herrera, K; Méndez, N. Prevalencia de síntomas de asma, dermatitis atópica y rinitis en la población pediátrica que asisten al Hospital Roosevelt. 2017, Jan.; Rev. Fac. Med. 2017, 1(Segunda Época), En–Jun No. 22. https://doi.org/10.37345/23045329.v1i22.51
Peroni, D. G., Piacentini, G. L., Cametti, E., Chinellato, I., & Boner, A. L. Correlation between serum 25-hydroxyvitamin D levels and severity of atopic dermatitis in children. The British journal of dermatology, 2011, May; 164(5), 1078–1082. https://doi.org/10.1111/j.1365-2133.2010.10147.x
Hattangdi-Haridas, S.R., Lanham-New, S.A., Wong, W.H.S., Ho, M.H.K. & Darling, A.L. Vitamin D deficiency and effects of vitamin D supplementation on disease severity in patients with atopic dermatitis: A systematic review and meta-analysis in adults and children. Nutrients. 2019, Aug.; 11(8): 1854. https://doi.org/10.3390/nu11081854
Merker, M., Amsler, A., Pereira, R., Bolliger, R., TRibolet, P., Braun, N., Hoess, C., Pavlicek, V., Bilz, S., Sigrist, S., Brändle, M., Henzen, C., Thomann, R., Rutishauser, J., Aujesky, D., Rodondi, N., Donzé, J., Stanga, Z., Mueller, B., Schuetz, P. Vitamin D deficiency is highly prevalent in malnourished inpatients and associated with higher mortality: A prospective cohort study. Medicine (/Baltimore). 2019, Nov.; 98(48): e18113. https://doi.org/10.1097/MD.0000000000018113
Ministerio de Salud Pública y Asistencia Social (MSPAS), Instituto Nacional de Estadística (INE), Secretaría de Planificación y Programación de la Presidencia (SEGEPLAN), e ICF International. VI Encuesta Nacional de Salud Materno Infantil 2014-2015. Informe Final. Guatemala, MSPAS/INE/ICF. https://www.ine.gob.gt/images/2017/encuestas/ensmi2014_2015.pdf
Palacios, C., and González, L. Is vitamin D deficiency a major global public health problem? The Journal of steroid biochemistry and molecular biology. 2014, Oct.; 144 Pt A: 138-145. https://doi.org/10.1016/j.jsbmb.2013.11.003
Við Streym, S. Hojskov, C.S., Moller, U.K., Heickendorff, L., Vestergaard, P., Mosekilde, L., Rejnmark, L. Vitamin D Content in Human Breast Milk: A 9-Mo Follow-up Study. The American Journal of Clinical Nutrition. 2016, January; 103(1): 107–114. https://doi.org/10.3945/ajcn.115.115105
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